PD Dr. Vivianne Irene Otto

Research Interests

• The glycomes of endothelial cells in different vessel types
  
• The roles of endothelial glycans in cell-cell interactions

Positions held

Since 09/2021
Lecturer in MSc course "Glycosylation" (BME316), University of Zurich, Switzerland

Since 02/2011
Senior scientist and lecturer (60% part time) Pharmacogenomics, Inst. of Pharmaceutical Sciences, ETH Zurich, Switzerland

Since 01/2011
Responsible for the Federal Exams of Pharmacy at ETH Zurich (Standortverantwortliche)

04/2015 - 10/2017
Member of the steering committee for the revision of the MSc courses Pharmacy and Pharmaceutical Sciences at the Institute of Pharmaceutical Sciences, ETH Zurich

09/2007 - 10/2017
Lecturer of the Master course "Molecular Mechanisms of Drug Actions and Targets" Inst. of Pharmaceutical Sciences, ETH Zurich, Switzerland

04/2009 – 06/2012
Specialist on pharmaceutical information (20% part time), Information Center Chemistry Biology Pharmacy, ETH Zurich, Switzerland

10/2006 – 03/2008
Designer and organizer of the courses in natural sciences and medicine (40% part time), People’s University Zurich (Volkshochschule Zürich), Switzerland

10/2005 – 07/2007
Deputy lecturer in Medicinal Chemistry and Biophysics, Inst. of Pharmaceutical Sciences, Dept. of Chemistry and Applied Biosciences, ETH Zurich, Switzerland

07/2003 – 03/2005
Senior Scientific Assistant (Oberassistentin), Inst. of Pharmaceutical Sciences, Dept. of Chemistry and Applied Biosciences, ETH Zurich, Switzerland

05/2001 – 05/2003
Research Fellow, Center for Medical Glycobiology, Department of Biochemistry and Molecular Biology, Oklahoma University Health Sciences Center, Oklahoma City, OK, USA

12/1997 – 04/2001
Scientific Assistant, Research Institute, Dept. of Surgery, University Hospital of Zurich, Switzerland

11/1992 – 04/1997
Research Assistant, PHD student, Institute of Clinical Chemistry, University Hospital of Zurich, Switzerland

11/1992 – 04/1997
Editor and writer of the pharmaceutical newsletter for clinicians “Blickpunkt Apotheke” (20% part time) Kantonsapotheke Zurich, Switzerland

10/1989 – 09/1992
Pharmacist, deputy head of department "Offizin", Kantonsapotheke Zurich, Switzerland

12/1987 – 09/1989
Pharmacist, deputy head of pharmacy, Pharmacy Höschgasse, Zurich, Switzerland

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Publications

2021

• D’Addio M, Frey J, Tacconi C, Commerford CD, Halin C, Detmar M, Cummings RD, Otto VI. (2021) Sialoglycans on lymphatic endothelial cells augment interactions with Siglec-1 (CD169) of lymph node macrophages. FASEB J. 35(11): e22017. doi: 10.1096/fj.202100300R.  

2020

• D’Addio M, Frey J, Otto VI (2020) The manifold roles of sialic acid for the biological functions of endothelial glycoproteins. Glycobiology, 30, 8: 490–499. doi: 10.1093/glycob/cwaa008
  
• Roudnicky F, Poyet C, Buser L, Saba K, Wild P, Otto VI, Detmar M. (2020) Characterization of tumor blood vasculature expression of human Invasive bladder cancer by laser capture microdissection and transcriptional profiling. Am J Pathol. 190(9): 1960-1970. doi: 10.1016/j.ajpath.2020.05.020.
  

2018

• Kut E, Sieroka N, Otto VI, Folkers G. (2018) Teaching Students to Reflect Critically on Their Own Research in the Pharmaceutical Sciences. ChemMedChem, Latest News, November 01, 2018
  
• Sieroka N, Otto VI, Folkers G. (2018) Guest Editorial: Critical Thinking in Education and Research – Why and How? Angew. Chem. Int Ed. 57: 16574-16575
• Sieroka N, Otto VI, Folkers G. (2018) Gast-Editorial: Kritisches Denken in Lehre und Forschung – warum und wie? Angew. Chem. 130: 16812-16813
  
• Roudnicky F, Yoon SY, Poghosyan S, Schwager S, Poyet C, Vella G, Bachmann SB, Karaman S, Shin JW, Otto VI, Detmar M. (2018) Alternative transcription of a shorter, non-antiangiogenic thrombospondin-2 variant in cancer-associated blood vessels. Oncogene, 37(19): 2573-2585. doi: 10.1038/s41388-018-0129-z.

2017

• Roudnicky F, Dieterich LC, Poyet C, Buser L, Wild P, Tang D, Camenzind P, Ho CH, Otto VI, Detmar M. (2017) High expression of insulin receptor on tumor-associated blood vessels in invasive bladder cancer predicts poor overall and progression-free survival, J Pathol, 242(2): 193-205. doi: 10.1002/path.4892

2016

• Graf R, Grüntzig, K, Boo G, Hässig M, Axhausen KW, Fabrikant S, Welle M, Meier D, Guscetti F, Folkers G, Otto V, Pospischil A. (2016) Swiss Feline Cancer Registry 1965–2008: the Influence of Sex, Breed and Age on Tumour Types and Tumour Locations. J Comp Pathol. 2016 Feb-Apr;154(2-3):195-210. doi: 10.1016/j.jcpa.2016.01.008

2015

• Graf R, Grüntzig K, Hässig M, Axhausen KW, Fabrikant S, Welle M, Meier D, Guscetti F, Folkers G, Otto VI, Pospischil A. (2015) Swiss Feline Cancer Registry: A retrospective study of the occurrence of tumours in cats in Switzerland from 1965 to 2008. J. Comp Pathol, 153: 266-277

2014

• Bianchi R, Fischer E, Yuen D, Ernst E, Chen L, Otto VI, Yuen D, Detmar M. (2014) Mutation of threonin 34 in mouse podoplanin-Fc reduces CLEC-2 binding and toxicity in vivo while retaining anti-lymphangiogenic activity. J Biol Chem, 89(30): 21016-21027
• Otto, VI. Wenn Wiesenkräuter sich erinnern, horizonte (SNF) Nr. 99, Januar 2014, 28-29.

2013

• Marino D, Angehrn Y, Klein S, Riccardi S, Baenziger-Tobler N, Otto VI, Pittelkow M, Detmar M. (2013) Activation of the epidermal growth factor receptor promotes lymphangiogenesis in the skin, J. Dermatol. Sci. 71(3): 184-94
• Otto, VI. Oenotherapie. In: Heilen – Gesunden: Das andere Arzneibuch. Festschrift zum 60. Geburtstag von Gerd Folkers, Kut E. und Schmid M. (Hg), Edition Collegium Helveticum 9, Zürich 2013
• Roudnicky F, Poyet C, Wild P, Krampitz S, Negrini F, Huggenberger R, Rogler A, Stöhr R, Hartmann A, Provenzano M, Otto VI, Detmar M. (2013) Endocan is upregulated on tumor vessels in invasive bladder cancer where it mediates VEGF-A-induced angiogenesis. Cancer Res, 73: 1097-106

2012

• Otto VI, Gefährliche Furchtlosigkeit. horizonte (SNF), Juni 2012
• Otto VI, Frühe Prognosen für Frühgeborene. horizonte (SNF), März 2012

2011

• Otto V. Das doppelte Geschenk der Narkosegase, horizonte (SNF), März 2011
• Tongzhong J, Otto V.I., Cummings R.D. (2011) The Tn Antigen — Structural Simplicity and Biological Complexity, review, Angewandte Chemie, International Edition, 50 (8): 1770-1791 (PDF)
• Tongzhong J, Otto V.I, Cummings R.D. (2011) Das Tn-Antigen – strukturell einfach und biologisch complex, Aufsatz, Angewandte Chemie, 123 (8): 1808-1830

2010

• Otto VI. Totgesagte leben länger, horizonte (SNF), September 2010, 20
• Otto V. Nervenzellen in Atemnot, horizonte (SNF), März 2010, 21.

2009

• Otto V. Kinderlos lebts sich länger, horizonte (SNF), Dezember 2009, 20
• Folkers G., Otto V.I. Qualität ist nicht messbar – Quantifizierung und multilaterale Übereinkünfte als Surrogate, Swiss Pharma 9/09, 19-23
• Otto V.I. Glykoproteine als Biopharmazeutika: Faszination und Tücken der Komplexität, PharmaJournal 01/2009, 5-8

2008

• Otto V.I, Schutz vor Vogelgrippeviren, Neue Zürcher Zeitung, Rubrik Forschung und Technik, 20.2.2008, B 3
• Schurpf T, Callewaert N, Meyer M.J.T, Trankle C, Laroy W, Cummings R.D, Otto V.I, (2008) Consequences of soluble ICAM-1 N-glycan alterations on receptor binding and signaling kinetics in mouse astrocytes, Open Glycoscience 1 (12): 40-51

2006

• Otto V.I., Damoc E, Cueni L.N, Schürpf T, Frey R, Ali S, Callewaert N, Moise A, Leary J, Folkers G, Przybylski M. (2006) N-Glycan Structures and N-Glycosylation Sites of Mouse Soluble Intercellular Adhesion Molecule-1 Revealed by MALDI-TOF and FTICR Mass Spectrometry, Glycobiology, 16(11): 1033-1044 (PDF)

2004

• Rancan M, Bye N, Otto V.I, Trentz O, Kossmann T, Frentzel S, Morganti-Kossmann M.C. (2004) The chemokine fractalkine in patients with severe traumatic brain injury and a mouse model of closed head injury, Journal of Cerebral Blood Flow and Metabolism, 24:1110-1118
• Otto V.I, Schürpf T, Folkers G, Cummings R.D. (2004) Sialylated complex-type N-glycans Enhance the Signaling Activity of Soluble Intercellular Adhesion Molecule-1 in Mouse Astrocytes, Journal of Biological Chemistry, 279(34): 35201-35209 (PDF)

2003

• Leppänen A, Yago, T, Otto V. I, McEver R.P, Cummings, R.D. (2003) Model glycosulfopeptides from P-selectin glycoprotein ligand-1 require tyrosine sulfation and a core 2-branched O-glycan to bind to L-selectin, Journal of Biological Chemistry, 278 (29): 26391-400

2002

• Yatsiv I, Morganti-Kossmann M.C, Perez D, Dinarello C.A, Novick D, Rubinstein M, Otto V.I, Rancan M, Kossmann T, Redaelli C.A, Trentz O, Shohami E, Stahel P. (2002) Elevated intracranial IL-18 in humans and mice after traumatic brain injury and evidence of neuroprotective effects of IL-18 binding protein (IL-18BP) after experimental closed head injury, Journal of Cerebral Blood Flow and etabolism, 22 (8): 971-978
• Otto V.I, Gloor S.M, Frentzel S, Gilli U, Ammann E, Hein A.E, Folkers G, Trentz O, Kossmann T, Morganti-Kossmann M.C. (2002) The production of macrophage inflammatory protein-1 induced by soluble intercellular adhesion molecule-1 in mouse astrocytes is mediated by src tyrosine kinases and p42/44 mitogen-activated protein kinase, Journal of Neurochemistry, 80: 824-834

1991-2001

• Rancan M, Otto V.I, Hans V.H.J, Gerlach I, Jork R, Trentz O, Kossmann T, Morganti-Kossmann MC. (2001) Upregulation of ICAM-1 and MCP-1 but not of MIP-2 and sensorimotor deficit in response to traumatic axonal injury in rats, Journal of Neuroscience Research, 63: 438-446
• Morganti-Kossmann M.C, Rancan M, Otto V.I, Stahel P.F, Kossmann T. (2001) Role of cerebral inflammation after traumatic brain injury: A revisited concept, Shock, 16 (3): 65-177
• Morganti-Kossmann M.C, Rancan M, Stahel P.M, Otto V.I, Kossmann T, Inflammatory response to traumatic brain injury. In: Brain Injury. Clark S.B, Kochanek P. (eds), pp 99-114, Kluwer Academic Publishers, Boston, 2001
• Otto V.I, Stahel P.F, Rancan M, Kariya K, Shohami E, Yatsiv I, Eugster H.P, Kossmann T, Trentz O, Morganti-Kossmann M.C. (2001) Regulation of chemokines and chemokine receptors after experimental closed head injury, NeuroReport, 12 (9): 2059-2064
• Stahel P.F, Shohami E, Younis F.M, Kariya K, Otto V.I, Lenzlinger P.M, Eugster H.P, Trentz O, Kossmann T, Morganti-Kossmann M.C. (2000) Experimental closed head injury: analysis of neurological outcome, blood-brain barrier dysfunction, and intracranial polymorphonuclear leukocyte infiltration in mice deficient in genes for ro-inflammatory cytokines, Journal of Cerebral Blood Flow and Metabolism, 20: 369-380
• Morganti-Kossmann M.C, Rancan M, Otto V.I, Stahel P.F, Kossmann T. (2000) Intracranial inflammation in traumatic brain injury: from patients to animal models and cell cultures, Recent Res. Devel. Neurochem, 3:257-274
• Morganti-Kossmann M.C, Otto V.I, Stahel P.F, Kossmann T. (2000) The role of inflammation in neurological disease, Current Opinion in Critical Care, 6 (2): 98-109
• Otto V.I, Heinzel-Pleines U. E, Gloor S.M, Kossmann T, Trentz O, Morganti-Kossmann M.C. (2000) TNF-α and soluble ICAM-1 induce MIP-2 secretion with distinct kinetics, Journal of Neuroscience Research, 60(6): 733-742. (PDF)
• Hans V.H.J, Kossmann T, Joller H, Otto V.I, Morganti-Kossmann M.C. (1999) Interleukin-6 and its soluble receptor in serum and cerebrospinal fluid after cerebral trauma, NeuroReport, 10: 409-412
• Otto V.I, Schär B.K, Sulser T, Hänseler E. (1998) Specific determination of germ cell alkaline phosphatase for early diagnosis and monitoring of seminoma: performance and limitations of different analytical techniques, Clinica Chimica Acta, 273: 131-147
• Otto V.I, Hasler C, Pletscher W. (1997) An update on the safety of medicinal products derived from human plasma, European Hospital Pharmacy, 3: 66-70
• Schär B.K, Otto V.I, Hänseler E. (1997) Simultaneous detection of all four alkaline phosphatase isoenzymes in human germ cell tumors using reverse transcription-PCR, Cancer Research, 57: 3841-3846
• Otto V.I, Fried R, Wiederkehr F, Hänseler E. (1995) Separation of the two most closely related isoenzymes of alkaline phosphatase by two-dimensional electrophoresis, Electrophoresis, 16: 1284-1288
  Otto V.I, Fleisch, Fett, Faserstoffe und Darmkrebs, Neue Zürcher Zeitung, Rubrik Forschung und Technik, 3.4.1991, S. 79

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