Publications

2023

Spera I, Cousin N, Ries M, Kedracka A, Castillo A, Aleandri S, Vladymyrov M, Mapunda JA, Engelhardt B, Luciani P, Detmar M, Proulxa ST (2023) Open pathways for cerebrospinal fluid outflow at the cribriform plate along the olfactory nerves. EBioMedicine 2023 Apr 10;91:104558. https://doi.org/10.1016/j.ebiom.2023.104558

Singhal D, Börner K, Chaikof EL, Detmar M, Hollmén M, Iliff JJ, Itkin M, Makinen T, Oliver G, Padera TP, Quardokus EM, Radtke AJ, Suami H, Weber GM, Rovira II, Muratoglu SC, Galis ZS (2023) Mapping the lymphatic system across body scales and expertise domains: A report from the 2021 National Heart, Lung, and Blood Institute workshop at the Boston Lymphatic Symposium. Front Physiol. 2023 Feb 6;14:1099403. doi: 10.3389/fphys.2023.1099403. PMID: 36814475; PMCID: PMC9939837.

Brunner LM, He Y, Cousin N, Scholl J, Albin LK, Schmucki B, Supersaxo S, Restivo G, Hafner J, Neri D, Werner S, Detmar M (2023) Promotion of Lymphangiogenesis by Targeted Delivery of VEGF-C Improves Diabetic Wound Healing. Cells. 2023 Feb 1;12(3):472. doi: 10.3390/cells12030472. PMID: 36766814; PMCID: PMC9913977.

Kim J, He Y, Tormen S, Kleindienst P, Ducoli L, Restivo G, Drach M, Levesque MP, Navarini AA, Tacconi C, Detmar M (2023) The p300/CBP Inhibitor A485 Normalizes Psoriatic Fibroblast Gene Expression In Vitro and Reduces Psoriasis-Like Skin Inflammation In Vivo. J Invest Dermatol. 2023 Mar;143(3):431-443.e19. doi: 10.1016/j.jid.2022.09.004. Epub 2022 Sep 26. PMID: 36174717.

2022

Cousin N, Bartel S, Scholl J, Tacconi C, Egger A, Thorhallsdottir G, Neri D, Dieterich LC, Detmar M (2022) Antibody-Mediated Delivery of VEGF-C Promotes Long-Lasting Lymphatic Expansion That Reduces Recurrent Inflammation. Cells. 2022 Dec 31;12(1):172. doi: 10.3390/cells12010172. PMID: 36611965; PMCID: PMC9818868.

Wolf S, Rannikko JH, Virtakoivu R, Cinelli P, Felmerer G, Burger A, Giovanoli P, Detmar M, Lindenblatt N, Hollmén M, Gousopoulos E (2022) A distinct M2 macrophage infiltrate and transcriptomic profile decisively influence adipocyte differentiation in lipedema. Front Immunol. 2022 Dec 20;13:1004609. doi: 10.3389/fimmu.2022.1004609. PMID: 36605202; PMCID: PMC9809281.

Sibler E, He Y, Ducoli L, Rihs V, Sidler P, Puig-Moreno C, Frey J, Fujimoto N, Detmar M, Dieterich LC (2022) Immunomodulatory Responses of Subcapsular Sinus Floor Lymphatic Endothelial Cells in Tumor-Draining Lymph Nodes. Cancers (Basel). 2022 Jul 24;14(15):3602. doi: 10.3390/cancers14153602. PMID: 35892863; PMCID: PMC9330828.

He Y, Kim J, Tacconi C, Moody J, Dieterich LC, Anzengruber F, Maul JT, Gousopoulos E, Restivo G, Levesque MP, Lindenblatt N, Shin JW, Hon CC, Detmar M (2022) Mediators of Capillary-to-Venule Conversion in the Chronic Inflammatory Skin Disease Psoriasis. J Invest Dermatol. 2022 Dec;142(12):3313-3326.e13. doi: 10.1016/j.jid.2022.05.1089. Epub 2022 Jun 28. PMID: 35777499.

Dieterich LC, Tacconi C, Ducoli L, Detmar M (2022) Lymphatic vessels in cancer. Physiol Rev. 2022 Oct 1;102(4):1837-1879. doi: 10.1152/physrev.00039.2021. Epub 2022 Jun 30. PMID: 35771983.

Yoon SY, Detmar M (2022) Sostdc1 Secreted from Cutaneous Lymphatic Vessels Acts as a Paracrine Factor for Hair Follicle Growth. Curr Issues Mol Biol. 2022 May 12;44(5):2167-2174. doi: 10.3390/cimb44050146. PMID: 35678675; PMCID: PMC9164032.

He Y, Tacconi C, Dieterich LC, Kim J, Restivo G, Gousopoulos E, Lindenblatt N, Levesque MP, Claassen M, Detmar M (2022) Novel Blood Vascular Endothelial Subtype-Specific Markers in Human Skin Unearthed by Single-Cell Transcriptomic Profiling. Cells. 2022 Mar 25;11(7):1111. doi: 10.3390/cells11071111. PMID: 35406678; PMCID: PMC8997372.

Kirsch C, Fehr D, Babity S, Polomska A, Detmar M, Bonmarin M, Brambilla D (2022) Development of a diffusion-weighed mathematical model for intradermal drainage quantification. Drug Deliv Transl Res. 2022 Apr;12(4):897-905. doi: 10.1007/s13346-021-01114-1. Epub 2022 Feb 11. PMID: 35147893.

Kim J, Gousopoulos E, Faleschini TM, Hamburger M, Potterat O, Detmar M (2022) Pheophorbide a identified in an Eupatorium perfoliatum extract is a novel lymphatic vascular activator. Biomed Pharmacother. 2022 Mar;147:112664. doi: 10.1016/j.biopha.2022.112664. Epub 2022 Feb 4. PMID: 35131655.

Liu YH, Brunner LM, Rebling J, Ben-Yehuda Greenwald M, Werner S, Detmar M, Razansky D (2022) Non-invasive longitudinal imaging of VEGF-induced microvascular alterations in skin wounds. Theranostics. 2022 Jan 1;12(2):558-573. doi: 10.7150/thno.65287. PMID: 34976201; PMCID: PMC8692907.

Nathanson SD, Detmar M, Padera TP, Yates LR, Welch DR, Beadnell TC, Scheid AD, Wrenn ED, Cheung K (2022) Mechanisms of breast cancer metastasis. Clin Exp Metastasis. 2022 Feb;39(1):117-137. doi: 10.1007/s10585-021-10090-2. Epub 2021 May 5. PMID: 33950409; PMCID: PMC8568733.

2021

D’Addio M, Frey J, Tacconi C, Commerford CD, Halin C, Detmar M, Cummings RD, Otto VI. (2021) Sialoglycans on lymphatic endothelial cells augment interactions with Siglec-1 (CD169) of lymph node macrophages. FASEB J. 35(11): e22017. doi: 10.1096/fj.202100300R.  

Polomska A, Gousopoulos E, Fehr D, Bachmann A, Bonmarin M, Detmar M, Lindenblatt N. (2021) Development and clinical validation of the LymphMonitor technology to quantitatively assess lymphatic function. Diagnostics 11(10), 1873; https://doi.org/10.3390/diagnostics11101873

Ducoli L, Agrawal S, Hon CC, Ramilowski JA, Sibler E, Tagami M, Itoh M, Kondo N, Abugessaisa I, Hasegawa A, Kasukawa T, Suzuki H, Carninci P, Shin JW, de Hoon MJL, Detmar M. (2021) The choice of negative control antisense oligonucleotides dramatically impacts downstream analysis depending on the cellular background. BMC Genomic Data 22:33. doi.org/10.1186/s12863-021-00992-1

Sibler E, He Y, Ducoli L, Keller N, Fujimoto N, Dieterich LC, Detmar M. (2021) Single-cell transcriptional heterogeneity of lymphatic endothelial cells in normal and inflamed murine lymph nodes. Cells. 10(6):1371. doi: 10.3390/cells10061371.

Cousin N, Cap S, Dihr M, Tacconi C, Detmar M, Dieterich LC. (2021) Lymphatic PD-L1 expression restricts tumor-specific CD8+ T cell responses. Cancer Res. 81(15): 4133-4144. doi: 10.1158/0008-5472.CAN-21-0633.

Grapotte M, Saraswat M, Bessière C, Menichelli C, Ramilowski JA, Severin J, Hayashizaki Y, Itoh M, Tagami M, Murata M, Kojima-Ishiyama M, Noma S, Noguchi S, Kasukawa T, Hasegawa A, Suzuki H, Nishiyori-Sueki H, Frith MC; FANTOM consortium; Chatelain C, Carninci P, de Hoon MJL, Wasserman WW, Bréhélin L, Lecellier CH. (2021) Discovery of widespread transcription initiation at microsatellites predictable by sequence-based deep neural network. Nat Commun. 2021 Jun 2;12(1):3297. doi: 10.1038/s41467-021-23143-7. Erratum in: Nat Commun. 2022 Mar 1;13(1):1200. PMID: 34078885; PMCID: PMC8172540.

Arasa J, Collado-​Diaz V, Kritikos I, Medina-​Sanchez JD, Friess MC, Sigmund EC, Schineis P, Hunter MC, Tacconi C, Paterson N, Nagasawa T, Kiefer F, Makinen T, Detmar M, Moser M, Lämmermann T, Halin C. (2021) Upregulation of VCAM-​1 in lymphatic collectors supports dendritic cell entry and rapid migration to lymph nodes in inflammation. J Exp Med. 218(7): e20201413. doi: 10.1084/jem.20201413. 

Nathanson SD, Detmar M, Padera TP, Yates LR, Welch DR, Beadnell TC, Scheid AD, Wrenn ED, Cheung K (2021) Mechanisms of breast cancer metastasis. Clin Exp Metastasis. 2022 Feb;39(1):117-137. doi: 10.1007/s10585-021-10090-2. Epub 2021 May 5. PMID: 33950409; PMCID: PMC8568733.

Tacconi C, Commerford CD, Dieterich LC, Schwager S, He Y, Ikenberg K, Friebel E, Becher B, Tugues S, Detmar M (2021) CD169+ lymph node macrophages have protective functions in mouse breast cancer metastasis. Cell Rep. 2021 Apr 13;35(2):108993. doi: 10.1016/j.celrep.2021.108993. PMID: 33852863.

Ducoli L, Detmar M. (2021) Beyond PROX1: transcriptional, epigenetic, and noncoding RNA regulation of lymphatic identity and function. Dev Cell. 56(4): 406-426. doi: 10.1016/j.devcel.2021.01.018.  

Ducoli L, Agrawal S, Sibler E, Kouno T, Tacconi C, Hon CC, Berger SD, Müllhaupt D, He Y, Kim J, D'Addio M, Dieterich LC, Carninci P, de Hoon MJL, Shin JW, Detmar M. (2021) LETR1 is a lymphatic endothelial-specific lncRNA governing cell proliferation and migration through KLF4 and SEMA3C. Nat Commun. 12(1): 925. doi: 10.1038/s41467-021-21217-0. PMID: 33568674

Tacconi C, He Y, Ducoli L, Detmar M. (2021) Epigenetic regulation of the lineage specificity of primary human dermal lymphatic and blood vascular endothelial cells. Angiogenesis. 24(1): 67-82. doi: 10.1007/s10456-020-09743-9.

2020

Silvestre-Roig C, Lemnitzer P, Gall J, Schwager S, Toska A, Yvan-Charvet L, Detmar M, Soehnlein O. (2020) Arterial Delivery of VEGF-C Stabilizes Atherosclerotic Lesions. Circ Res. 2021 Jan 22;128(2):284-286. doi: 10.1161/CIRCRESAHA.120.317186. Epub 2020 Nov 19. PMID: 33210556.

Tacconi C, He Y, Ducoli L, Detmar M. (2020) Epigenetic regulation of the lineage specificity of primary human dermal lymphatic and blood vascular endothelial cells. Angiogenesis. 2021 Feb;24(1):67-82. doi: 10.1007/s10456-020-09743-9. Epub 2020 Sep 12. PMID: 32918672; PMCID: PMC7921079.

Babity S, Polomska AK, Couture F, Bonmarin M, Fehr D, Detmar M, Brambilla D. (2020) Rational design of a fluorescent microneedle tattoo for minimally invasive monitoring of lymphatic function. J Control Release. 327: 350-359. doi: 10.1016/j.jconrel.2020.08.017.

Sesartić M, Ikenberg K, Yoon SY, Detmar M. (2020) Keratinocyte-Expressed Podoplanin is Dispensable for Multi-Step Skin Carcinogenesis. Cells. 2020 Jun 24;9(6):1542. doi: 10.3390/cells9061542. PMID: 32599908; PMCID: PMC7348927.

Roudnicky F, Poyet C, Buser L, Saba K, Wild P, Otto VI, Detmar M. (2020) Characterization of tumor blood vasculature expression of human Invasive bladder cancer by laser capture microdissection and transcriptional profiling. Am J Pathol.190(9): 1960-1970. doi: 10.1016/j.ajpath.2020.05.020

Dieterich LC, Tacconi C, Menzi F, Proulx ST, Kapaklikaya K, Hamada M, Takahashi S, Detmar M. (2020) Lymphatic MAFB regulates vascular patterning during developmental and pathological lymphangiogenesis. Angiogenesis. 23(3): 411-423. doi: 10.1007/s10456-020-09721-1

Sesartic K, Ikenberg K, Yoon SY, Detmar M. (2020) Keratinocyte-expressed podoplanin is dispensable for multi-step skin carcinogenesis. Cells. 9(6): 1542. doi: 10.3390/cells9061542

Fujimoto N, He Y, D'Addio M, Tacconi C, Detmar M, Dieterich LC. (2020) Single-cell mapping reveals new markers and functions of lymphatic endothelial cells in lymph nodes. PLoS Biol. 18(4): e3000704. doi: 10.1371/journal.pbio.3000704. eCollection 2020 Apr.

Bachmann SB, Proulx ST, He Y, Ries M, Detmar M. (2020) Differential effects of anaesthesia on the contractility of lymphatic vessels in vivo: authors' reply. J Physiol. 598(10): 2037. doi: 10.1113/JP279712

2019

Tacconi C, Schwager S, Cousin N, Bajic D, Sesartic M, Sundberg J, Neri D, Detmar M. (2019) Antibody-mediated delivery of VEGFC ameliorates experimental chronic colitis. ACS Pharmacol Transl Sci. 2(5): 342-352. doi: 10.1021/acsptsci.9b00037.

Ma Q, Schlegel F, Bachmann SB, Schneider H, Decker Y, Rudin M, Weller M, Proulx ST, Detmar M. (2019) Lymphatic outflow of cerebrospinal fluid is reduced in glioma. Sci Rep 9(1): 14815. doi: 10.1038/s41598-019-51373-9.

Dieterich LC, Kapaklikaya K, Cetintas T, Proulx ST, Commerford CD, Ikenberg K, Bachmann SB, Scholl J, Detmar M. (2019) Transcriptional profiling of breast cancer-associated lymphatic vessels reveals VCAM-1 as regulator of lymphatic invasion and permeability. Int J Cancer. 145(10): 2804-2815. doi: 10.1002/ijc.32594

Tacconi C, Ungaro F, Correale C, Arena V, Massimino L, Detmar M, Spinelli A, Carvello M, Mazzone M, Oliveira AI, Rubbino F, Garlatti V, Spanò S, Lugli E, Colombo FS, Malesci A, Peyrin-Biroulet L, Vetrano S, Danese S, D'Alessio S. (2019) Activation of the VEGFC/VEGFR3 pathway induces tumor immune escape in colorectal cancer. Cancer Res. 79(16): 4196-4210. doi: 10.1158/0008-5472.CAN-18-3657.0.0  

Yoon SY, Dieterich LC, Karaman S, Proulx ST, Bachmann SB, Sciaroni C, Detmar M. (2019) An important role of cutaneous lymphatic vessels in coordinating and promoting anagen hair follicle growth. PLoS One. 14(7): e0220341. doi: 10.1371/journal.pone.0220341

Yoon SY, Dieterich LC, Tacconi C, Sesartic M, He Y, Brunner L, Kwon O, Detmar M. (2019) An important role of podoplanin in hair follicle growth. PLoS One 14(7): e0219938. doi: 10.1371/journal.pone.0219938

Bachmann SB, Gsponer D, Montoya-Zegarra JA, Schneider M, Scholkmann F, Tacconi C, Noerrelykke SF, Proulx ST, Detmar M. (2019) A distinct role of the autonomic nervous system in modulating the function of lymphatic vessels under physiological and tumor-draining conditions. Cell Rep. 27(11): 3305-3314.e13. doi: 10.1016/j.celrep.2019.05.050.

Bachmann SB, Proulx ST, He Y, Ries M, Detmar M. (2019) Differential effects of anaesthesia on the contractility of lymphatic vessels in vivo. J Physiol. 597(11): 2841-2852. doi: 10.1113/JP277254

Schwager S, Detmar M. (2019) Inflammation and Lymphatic Function. Front Immunol. 10:308. doi: 10.3389/fimmu.2019.00308. eCollection 2019. Review.

Polomska AK, Proulx ST, Brambilla D, Fehr D, Bonmarin M, Brändli S, Meboldt M, Steuer C, Vasileva T, Reinke N, Leroux JC, Detmar M. (2019) Minimally-invasive method for the point-of-care quantification of lymphatic vessel function. JCI Insight. 4(4). pii: 126515. doi: 10.1172/jci.insight.126515

Ma Q, Ries M, Decker Y, Müller A, Riner C, Bücker A, Fassbender K, Detmar M, Proulx ST. (2019) Rapid lymphatic efflux limits cerebrospinal fluid flow to the brain. Acta Neuropathol. 137(1): 151-165. doi: 10.1007/s00401-018-1916-x

Montoya-Zegarra JA, Russo E, Runge P, Jadhav M, Willrodt AH, Stoma S, Nørrelykke SF, Detmar M, Halin C. (2019) AutoTube: a novel software for the automated morphometric analysis of vascular networks in tissues. Angiogenesis. 22(2):223-236. doi: 10.1007/s10456-018-9652-3.

2018

Schwager S, Renner S, Hemmerle T, Karaman S, Proulx ST, Fetz R, Golding-Ochsenbein AM, Probst P, Halin C, Neri D, Detmar M. (2018) Antibody-mediated delivery of VEGF-C potently reduces chronic skin inflammation. JCI Insight. 3(23). pii: 124850. doi: 10.1172/jci.insight.124850.

Commerford CD, Dieterich LC, He Y, Hell T, Montoya-Zegarra JA, Noerrelykke SF, Russo E, Röcken M, Detmar M. (2018) Mechanisms of Tumor-Induced Lymphovascular Niche Formation in Draining Lymph Nodes. Cell Rep. 25(13): 3554-3563.e4. doi: 10.1016/j.celrep.2018.12.002

Bachmann, SB, Detmar M, Proulx ST. (2018) Visualization and Measurement of Lymphatic Function In Vivo. Methods Mol Biol. 1846:197-211. doi: 10.1007/978-1-4939-8712-2_13

Ralvenius WT, Neumann E, Pagani M, Acuña MA, Wildner H, Benke D, Fischer N, Rostaher A, Schwager S, Detmar M, Frauenknecht K, Aguzzi A, Hubbs JL, Rudolph U, Favrot C, Zeilhofer HU. (2018) Itch suppression in mice and dogs by modulation of spinal α2 and α3GABAA receptors. Nat Commun. 2018 Aug 13;9(1):3230. doi: 10.1038/s41467-018-05709-0. PMID: 30104684; PMCID: PMC6089996.

Ma Q, Dieterich LC, Ikenberg K, Bachmann SB, Mangana J, Proulx ST, Amann VC, Levesque MP, Dummer R, Baluk P, McDonald DM, Detmar M. (2018) Unexpected contribution of lymphatic vessels to promotion of distant metastatic tumor spread. Sci Adv. 4: 8, eaat4758. doi: 10.1126/sciadv.aat4758

Brown M, Johnson LA, Leone DA, Majek P, Vaahtomeri K, Senfter D, Bukosza N, Schachner H, Asfour G, Langer B, Hauschild R, Parapatics K, Hong YK, Bennett KL, Kain R, Detmar M, Sixt M, Jackson DG, Kerjaschki D. (2018) Lymphatic exosomes promote dendritic cell migration along guidance cues. J Cell Biol. 217(6): 2205-2221. doi: 10.1083/jcb.201612051

Ma Q, Dieterich LC, Detmar M. (2018) Multiple roles of lymphatic vessels in tumor progression. Curr Opin Immunol. 53: 7-12. doi: 10.1016/j.coi.2018.03.018 Review.

Roudnicky F, Yoon SY, Poghosyan S, Schwager S, Poyet C, Vella G, Bachmann SB, Karaman S, Shin JW, Otto VI, Detmar M. (2018) Alternative transcription of a shorter, non-antiangiogenic thrombospondin-2 variant in cancer-associated blood vessels. Oncogene. 37(19): 2573-2585. doi: 10.1038/s41388-018-0129-z

Kajiya K, Bise R, Seidel C, Sato I, Yamashita T, Detmar M. (2018) Light-sheet microscopy reveals site-specific 3-dimensional patterns of the cutaneous vasculature and pronounced rarefication in aged skin. Dermatol Sci. pii: S0923-1811(18)30280-9. doi: 10.1016/j.jdermsci.2018.07.006

Yoshida Y, Kajiya K, Kishimoto J, Detmar M. (2018) Quantitative histological analyses and transcriptional profiling reveal structural and molecular changes of the dermal extracellular matrix in cellulite. J Dermatol Sci. pii: S0923-1811(18) 30271-8. doi: 10.1016/j.jdermsci.2018.06.010

2017

Ma Q, Ineichen BV, Detmar M, Proulx ST. (2017) Outflow of cerebrospinal fluid is predominantly through lymphatic vessels and is reduced in aged mice. Nat Commun, 8(1): 1434. doi: 10.1038/s41467-017-01484-6

Gousopoulos E, Proulx ST, Bachmann SB, Dieterich LC, Scholl J, Karaman S, Bianchi R, Detmar M. (2017) An important role of VEGF-C in promoting lymphedema development. J Invest Dermatol. 137(9): 1995-2004 doi: 10.1016/j.jid.2017.04.033

Dieterich LC, Ducoli L, Shin JW, Detmar M. (2017) Distinct transcriptional responses of lymphatic endothelial cells to VEGFR-3 and VEGFR-2 stimulation. Sci Data. 4:170106. doi: 10.1038/sdata.2017.106

de Rie D, Abugessaisa I, Alam T, Arner E, Arner P, Ashoor H, Åström G, Babina M, Bertin N, Burroughs AM, Carlisle AJ, Daub CO, Detmar M, Deviatiiarov R, Fort A, Gebhard C, Goldowitz D, Guhl S, Ha TJ, Harshbarger J, Hasegawa A, Hashimoto K, Herlyn M, Heutink P, Hitchens KJ, Hon CC, Huang E, Ishizu Y, Kai C, Kasukawa T, Klinken P, Lassmann T, Lecellier CH, Lee W, Lizio M, Makeev V, Mathelier A, Medvedeva YA, Mejhert N, Mungall CJ, Noma S, Ohshima M, Okada-Hatakeyama M, Persson H, Rizzu P, Roudnicky F, Sætrom P, Sato H, Severin J, Shin JW, Swoboda RK, Tarui H, Toyoda H, Vitting-Seerup K, Winteringham L, Yamaguchi Y, Yasuzawa K, Yoneda M, Yumoto N, Zabierowski S, Zhang PG, Wells CA, Summers KM, Kawaji H, Sandelin A, Rehli M; FANTOM Consortium, Hayashizaki Y, Carninci P, Forrest ARR, de Hoon MJL. (2017) An integrated expression atlas of miRNAs and their promoters in human and mouse. Nat Biotechnol, 35(9): 872-878. doi: 10.1038/nbt.3947

Noguchi S, Arakawa T, Fukuda S, Furuno M, Hasegawa A, Hori F, Ishikawa-Kato S, Kaida K, Kaiho A, Kanamori-Katayama M, Kawashima T, Kojima M, Kubosaki A, Manabe RI, Murata M, Nagao-Sato S, Nakazato K, Ninomiya N, Nishiyori-Sueki H, Noma S, Saijyo E, Saka A, Sakai M, Simon C, Suzuki N, Tagami M, Watanabe S, Yoshida S, Arner P, Axton RA, Babina M, Baillie JK, Barnett TC, Beckhouse AG, Blumenthal A, Bodega B, Bonetti A, Briggs J, Brombacher F, Carlisle AJ, Clevers HC, Davis CA, Detmar M, Dohi T, Edge ASB, Edinger M, Ehrlund A, Ekwall K, Endoh M, Enomoto H, Eslami A, Fagiolini M, Fairbairn L, Farach-Carson MC, Faulkner GJ, Ferrai C, Fisher ME, Forrester LM, Fujita R, Furusawa JI, Geijtenbeek TB, Gingeras T, Goldowitz D, Guhl S, Guler R, Gustincich S, Ha TJ, Hamaguchi M, Hara M, Hasegawa Y, Herlyn M, Heutink P, Hitchens KJ, Hume DA, Ikawa T, Ishizu Y, Kai C, Kawamoto H, Kawamura YI, Kempfle JS, Kenna TJ, Kere J, Khachigian LM, Kitamura T, Klein S, Klinken SP, Knox AJ, Kojima S, Koseki H, Koyasu S, Lee W, Lennartsson A, Mackay-Sim A, Mejhert N, Mizuno Y, Morikawa H, Morimoto M, Moro K, Morris KJ, Motohashi H, Mummery CL, Nakachi Y, Nakahara F, Nakamura T, Nakamura Y, Nozaki T, Ogishima S, Ohkura N, Ohno H, Ohshima M, Okada-Hatakeyama M, Okazaki Y, Orlando V, Ovchinnikov DA, Passier R, Patrikakis M, Pombo A, Pradhan-Bhatt S, Qin XY, Rehli M, Rizzu P, Roy S, Sajantila A, Sakaguchi S, Sato H, Satoh H, Savvi S, Saxena A, Schmidl C, Schneider C, Schulze-Tanzil GG, Schwegmann A, Sheng G, Shin JW, Sugiyama D, Sugiyama T, Summers KM, Takahashi N, Takai J, Tanaka H, Tatsukawa H, Tomoiu A, Toyoda H, van de Wetering M, van den Berg LM, Verardo R, Vijayan D, Wells CA, Winteringham LN, Wolvetang E, Yamaguchi Y, Yamamoto M, Yanagi-Mizuochi C, Yoneda M, Yonekura Y, Zhang PG, Zucchelli S, Abugessaisa I, Arner E, Harshbarger J, Kondo A, Lassmann T, Lizio M, Sahin S, Sengstag T, Severin J, Shimoji H, Suzuki M, Suzuki H, Kawai J, Kondo N, Itoh M, Daub CO, Kasukawa T, Kawaji H, Carninci P, Forrest ARR, Hayashizaki Y. (2017) FANTOM5 CAGE profiles of human and mouse samples. Sci Data, 4: 170112. doi: 10.1038/sdata.2017.112

Gousopoulos E, Karaman S, Proulx ST, Leu K, Buschle D, Detmar M. (2017) High-fat diet in the absence of obesity does not aggravate surgically induced lymphoedema in mice. Eur Surg Res. 58:180-192. doi: 10.1159/000461579

Roudnicky F, Dieterich LC, Poyet C, Buser L, Wild P, Tang D, Camenzind P, Ho CH, Otto VI, Detmar M. (2017) High expression of insulin receptor on tumor-associated blood vessels in invasive bladder cancer predicts poor overall and progression-free survival, J Pathol. 242(2): 193-205. doi: 10.1002/path.489

Dieterich LC, Ikenberg K, Cetintas T, Kapaklikaya K, Hutmacher C, Detmar M. (2017) Tumor-associated lymphatic vessels upregulate PDL1 to inhibit T-cell activation. Front Immunol. 8: 66. doi: 10.3389/fimmu.2017.00066

Teijeira A, Hunter MC, Russo E, Proulx ST, Frei T, Debes GF, Coles M, Melero I, Detmar M, Rouzaut A, Halin C. (2017) T Cell Migration from Inflamed Skin to Draining Lymph Nodes Requires Intralymphatic Crawling Supported by ICAM-1/LFA-1 Interactions. Cell Rep. 18(4): 857-865. doi: 10.1016/j.celrep.2016.12.078

Proulx ST, Ma Q, Andina D, Leroux JC, Detmar M. (2017) Quantitative measurement of lymphatic function in mice by noninvasive near-infrared imaging of a peripheral vein. JCI Insight, 2(1): e90861. doi: 10.1172/jci.insight.90861

Cui J, Hollmén M, Li L, Chen Y, Proulx ST, Reker D, Schneider G, Detmar M. (2017) New use of an old drug: inhibition of breast cancer stem cells by benztropine mesylate. Oncotarget. 8(1): 1007-1022. doi: 10.18632/oncotarget.13537

Bianchi R, Russo E, Bachmann SB, Proulx ST, Sesartic M, Smaadahl N, Watson SP, Buckley ChD, Halin C, Detmar M. (2017) Postnatal Deletion of Podoplanin in Lymphatic Endothelium Results in Blood Filling of the Lymphatic System and Impairs Dendritic Cell Migration to Lymph Nodes. Arterioscler Thromb Vasc Biol. 37(1): 108-117. doi: 10.1161/ATVBAHA.116.308020

2016
Gousopoulos E, Proulx ST, Bachmann SB, Scholl J, Dionyssiou D, Demiri E, Halin C, Dieterich LC, Detmar M. (2016) Regulatory T cell transfer ameliorates lymphedema and promotes lymphatic vessel function. JCI Insight, 1(16): e89081

Docherty JR, Steinhoff M, Lorton D, Detmar M, Schäfer G, Holmes A, Di Nardo A. (2016) Multidisciplinary Consideration of Potential Pathophysiologic Mechanisms of Paradoxical Erythema with Topical Brimonidine Therapy. Adv Ther. 33(11): 1885-1895

Karaman S, Hollmén M, Yoon SY, Alkan HF, Alitalo K, Wolfrum C, Detmar M. (2016) Transgenic overexpression of VEGF-C induces weight gain and insulin resistance in mice. Sci. Rep. 6: 31566. doi: 10.1038/srep31566

Ochsenbein AM, Karaman S, Proulx ST, Goldmann R, Chittazhathu J, Dasargyri A, Chong C, Leroux JC, Stanley ER, Detmar M. (2016) Regulation of lymphangiogenesis in the diaphragm by macrophages and VEGFR-3 signaling. Angiogenesis, 9(4): 513-24. doi: 10.1007/s10456-016-9523-8

Gousopoulos E, Proulx ST, Scholl J, Uecker M, Detmar M. (2016) Prominent Lymphatic Vessel Hyperplasia with Progressive Dysfunction and Distinct Immune Cell Infiltration in Lymphedema. Am J Pathol. 186(8): 2193-203. doi: 10.1016/j.ajpath.2016.04.006

Escobedo N, Proulx ST, Karaman S, Dillard ME, Johnson N, Detmar M, Oliver G. (2016) Restoration of lymphatic function rescues obesity in Prox1-haploinsufficient mice. JCI Insight. 1(2). pii: e85096

Klein S, Dieterich LC, Mathelier A, Chong Ch, Sliwa-Primorac A, Hong YK, Shin JW, Lizio M, Itoh M, Kawaji H, Lassmann T, Daub CO, Arner E, The FANTOM Consortium, Carninci P, Hayashizaki Y, Forrest AR, Wasserman WW, Detmar M. (2016) DeepCAGE transcriptomics identify HOXD10 as a transcription factor involved in the early lymphatic endothelial response to VEGF-C. J Cell Sci. 129(13): 2573-85

Christiansen AJ, Dieterich LC, Ohs I, Bachmann SB, Bianchi R, Proulx ST, Hollmén M, Aebischer D, Detmar M. (2016) Lymphatic endothelial cells attenuate inflammation via suppression of dendritic cell maturation. Oncotarget, 7(26): 39421-39435 doi: 10.18632/oncotarget.9820

Nishida-Fukuda H, Araki R, Shudou M, Okazaki H, Tomono Y, Nakayama H, Fukuda S, Sakaue T, Shirakata Y, Sayama K, Hashimoto K, Detmar M, Higashiyama S, Hirakawa S. (2016) Ectodomain Shedding of Lymphatic Vessel Endothelial Hyaluronan Receptor 1 (LYVE-1) is induced by VEGF-A. J. Biol. Chem, 291(20): 10490-500

Hollmén M, Karaman S, Schwager S, Lisibach A, Christiansen AJ, Maksimow M, Varga Z, Jalkanen S, Detmar M. (2016) G-CSF-regulates macrophage phenotype and associates with poor overall survival in human triple-negative breast cancer. Oncoimmunology 5(3): e1115177

Chong C, Scholkmann F, Bachmann SB, Luciani P, Leroux JC, Detmar M, Proulx ST. (2016) In vivo visualization and quantification of collecting lymphatic vessel contractility using near-infrared imaging. Sci Rep. 6: 22930. doi: 10.1038/srep22930

Brambilla, D, Proulx ST, Marschalkova P, Detmar M, Leroux JC. (2016) Microneedles for the noninvasive structural and functional assessment of dermal lymphatic vessels. Small, 12(8): 1053-61

Ochsenbein AM, Karaman S, Proulx ST, Berchtold M, Jurisic G, Stoeckli ET, Detmar M. (2016) Endothelial cell-derived Sema3A inhibits filopodia formation by blood vascular tip cells. Development, 143(4): 589-94

Dasargyri A, Hervella P, Christiansen A, Proulx S, Detmar M, Leroux JC. (2016) Findings questioning the involvement of Sigma-1 receptor in the uptake of anisamide-decorated particles. J Control Release, 224: 229-38

Dieterich LC, Detmar M. (2016) Tumor lymphangiogenesis and new drug development. Adv Drug Deliv Rev. 99(Pt B): 148-60